Impact Of Cryoablation On Tumor Immunity
نویسنده
چکیده
.......................................................................................................19 Introduction...................................................................................................21 Results...........................................................................................................25 Discussion....................................................................................................42 Chapter 2: Cryoablation of neu-expressing TUBO Mammary Adenocarcinoma Abstract........................................................................................................45 Introduction.....................................................................................................47 Results..........................................................................................................49 Discussion....................................................................................................69 Chapter 3: Cryoablation of Her2-expressing D2F2/E2 Mammary Adenocarcinoma Abstract........................................................................................................72 Introduction...................................................................................................74 Results.........................................................................................................75 Discussion........................................................................................................98 General Conclusions...............................................................................................101 Appendix..............................................................................................................104 References...............................................................................................................106 Abstract................................................................................................................126 Autobiographical Statement......................................................................................128
منابع مشابه
Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates HER2/neu immunity.
Percutaneous cryoablation is a minimally invasive procedure for tumor destruction, which can potentially initiate or amplify antitumor immunity through the release of tumor-associated antigens. However, clinically efficacious immunity is lacking and regional recurrences are a limiting factor relative to surgical excision. To understand the mechanism of immune activation by cryoablation, compreh...
متن کاملMicroenvironment and Immunology Cryotherapy with Concurrent CpG Oligonucleotide Treatment Controls Local Tumor Recurrence andModulates HER2/neu Immunity
Percutaneous cryoablation is a minimally invasive procedure for tumor destruction, which can potentially initiate or amplify antitumor immunity through the release of tumor-associated antigens. However, clinically efficacious immunity is lacking and regional recurrences are a limiting factor relative to surgical excision. To understand the mechanism of immune activation by cryoablation, compreh...
متن کاملCyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation.
Cryoablation of a solitary tumor mass releases intact tumor antigens and can induce protective antitumor immunity but has limited efficacy in the treatment of established metastatic cancer. Cyclophosphamide (Cy), an anticancer drug, selectively depletes regulatory T cells (T(reg)s) and attenuates suppression of antitumor immunity. We used a BALB/c mouse model of metastatic colon cancer to inves...
متن کاملTumor-Specific Immunity Induced by Cryoablation in a Murine Renal Cell Carcinoma Model
PURPOSE To evaluate tumor-specific immunity and define the mechanisms involved in the cryoimmunologic response, we compared the tumor control efficacy and immunologic responses of cryoablation with those of surgical excision in a tumor rechallenge model. MATERIALS AND METHODS Sixty BALB/c mice with RENCA tumors that were generated in the left flank area underwent cryoablation or radical excis...
متن کاملPotent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Thermal ablation to destroy tumor tissue may help activate tumor-specific T cells by elevating the presentation of tumor antigens to the immune system. However, the antitumor activity of these T cells may be restrained by their expression of the inhibitory T-cell coreceptor CTLA-4, the target of the recently U.S. Food and Drug Administration-approved antibody drug ipilumimab. By relieving this ...
متن کامل